2College of Pharmacy, G.C. University, Faisalabad, Pakistan, Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Definite cause of necrotizing enterocolitis is still unknown. However, Pseuodomonas aeruginosa is suspected to be a cause of this disease in infants [4-6]. Many other causes of necrotizing enterocolitis include poor immune system, intestinal flora, prolonged use of antibiotics and oral feeding other than the breast milk of the mother. It is proposed that oral feeding in infants increases the risk of necrotizing enterocolitis ten times greater than the infants that having feed from the mother directly. [7,8] Its reason is that the breast milk of the mother has anti-infective property that prevents the infants against certain diseases. 
As the causative agent of necrotizing enterocolitis is not confirmed, so, its pathogenesis is also not exactly known. [10-12] However,
- Infants those having intestinal flora like Staphylococcus aureus and E. coli are more susceptible to NEC.
- Long term antibiotic therapy causes the change in the internal environment of the GIT that may lead to necrosis.
- Immature intestinal mucosa may also the cause of NEC.
Initial symptoms are feeding disturbance, bloody stools due to mucosal damage and abdominal distension. Late symptoms are perforations in the various parts of GIT, peritonitis and hypotension [13,14].
Necrotizing enterocolitis is diagnosed clinically but it also requires certain imaging techniques to confirm the disease like radiography, ultrasonography, etc. radiographic signs in infant having NEC are expansion of bowel loop (due to filling of gas) and pneumoperitoneum (free air outside the bowel within the abdomen) [15,16]. Ultrasonography also proves an effective technique in the diagnosis of NEC. Mostly abdominal distension, intestinal necrosis and hemorrhage like symptoms are seen in case of necrotizing enterocolitis in infants .
[Modified from https://phil.cdc.gov/Details.aspx?pid=855]
Surgical treatment of NEC is possible but it may cause certain complications like short bowel syndrome and suppression in neural development. During surgery dead bowel contents are removed from the body [18-20]. Rather than the treatment, preventive measures are very useful to minimize the risk of NEC. Prevention is the best cure of NEC because there is many causes of getting NEC in infants, in other words NEC has multifactorial nature regarding its etiology [21,22].
- Minimize oral feeding.
- Stoppage of antibiotic therapy
- Use only human milk or milk from donor if mother's milk is unavailable.
- Recent study shows that the use of higher rate of lipid infusion in the first week of life resulted in no infant with NEC .
- Reber KM and Nankervis CA. “Necrotizing enterocolitis preventative strategies”. Clinics in Perinatology 31.1 (2004): 157-167.
- Caplan MS. “Pathogenesis and Prevention of Neonatal Necrotizing Enterocolitis”. Fetal and Neonatal Physiology (2004).
- Stoll BJ. “Epidemiology of Necrotizing Enterocolitis”. Clinics in perinatology 21.2 (1994): 205-218.
- Kanto WP., et al. “Recognition and Medical management of necrotizing enterocolitis”. Clinics in Perinatology 21.2 (2000): 335-346.
- Morrison SC and Jacobson JM. “The radiology of necrotizing enterocolitis”. Clinics in Perinatology 21.2 (2004): 347-364.
- Bell MJ., et al. “Neonatal necrotizing enterocolitis. Therapeutic decision based upon clinical staging”. Annals of Surgery 187 (2001): 1-7.
- Sato TT and Oldham KT. “Abdominal drain placement versus laparotomy for necrotizing enterocolitis with perforation”. Clinics in Perinatology 31.3 (2004): 577-589.
- Sharma R., et al. “Portal venous gas and surgical outcome of neonatal necrotizing enterocolitis”. Journal of Pediatric Surgery 40.2 (2005): 371-376.
- Hintz SR., et al. “NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis”. Pediatrics 115.5 (2005): 696-703.
- Rees CM., et al. “Surgical strategies for necrotising enterocolitis: a survey of practice in the United Kingdom”. Archives of Disease in Childhood. Fetal and Neonatal Edition 90.2 (2005): F152-F155.
- Lin HC., et al. “Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants”. Pediatrics 115.1 (2005): 1-4.
- Hsueh W., et al. “Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts”. Pediatric and Developmental Pathology 6.1 (2003): 6-23.
- Amin HJ., et al. “Arginine supplementation prevents necrotizing enterocolitis in the premature infant”. Journal of Pediatrics 140.2 (2002): 425-431.
- Reber KM., et al. “Newborn intestinal circulation. Physiology and pathophysiology”. Clinics in Perinatology 29 (2002): 23-39.
- Lin HC., et al. “Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants”. Pediatrics 115 (2005): 1-4.
- Dani C., et al. “Probiotics feeding in prevention of urinary track infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double blind study”. Biology of the Neonate 82 (2002): 103-108.
- Lucas A and Cole TJ. “Breastmilk neonatalnecrotizing enterocolitis”. Lancet 336 (1990): 1519-1523.
- Schanler RJ., et al. “Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula”. Pediatrics 103 (1999): 1150-1157.
- Eibl MM., et al. “Prevention of necrotizing enterocolitis in low birth weight infants by IgA-IgGn feeding”. The New England Journal of Medicine 319 (1998): 1-7.
- Rubaltelli FF., et al. “Prevention of necrotizing enterocolitis in neonates at risk by oral administration of monomeric IgG”. Developmental Pharmacology and Therapeutics17 (1991): 138-143.
- Lawrence G., et al. “Enteral human IgG for prevention of necrotizing enterocolitis: a placebo controlled, randomized trial”. Lancet 357 (2001): 2090-2094.
- Orrhage K and Nord CE. “Factors controlling the bacterial colonization of the intestine in breastfed infants”. Acta Paediatrica 88 (1999): 47-57.
- Thompson C., et al. “Lactobacillus acidophilus sepsis in a neonate”. Journal of Perinatology 21 (2001): 288-260.