Po-Chang Chiang and Karthik N. Commentary: Liquid-filled Formulations. J of drug, 2018, 1(3). 7-9 .
Po-Chang Chiang et al. An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3K-δ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs. 2017. In print. Journal of Pharmaceutical Sciences.Selected for inclusion in the Samuel H. Yalkowsky Dedicated Issue.
Po-Chang Chiang et al. An Investigation of Dose Dependent Limiting Factors for Oral Bioavailability: A Case Study of PI3K-δ Inhibitor. J. Pharm. Sci. 2016 Volume 105, Issue 6, Pages 1802–1809.
Po-Chiang Chiang, J Warner, D Tung. The Spatial Response of Penh as a Secondary Readout for the Airway Hyper-reactivity in Three Different Rodent Models of Airway Inflammation: a Pilot Comparison Study. British Journal of Applied Science & Technology. 2016, 13(1), 1-10.
Po-Chiang Chiang, Kimberly R Kam, Kang-Jye Chou. Investigation of Intrinsic dissolution Rate Based Absorption Model to Predict Exposure Enhancement via Nanosuspension Formulation of 1, 3-Dicyclohexylurea in Rats. Lett Appl NanoBioScience. 2015,4(1), 241-246.
Kan-Jye Chou, Linda Bao, Kimberly R Kam, Christine Gu, Po-Chang Chaing ( both 1st author), Evaluation of Nanoparticle Formation Feasibility upon Wet Milling based on Physicochemical Properties of Drug Molecules. Lett Appl NanoBioScience. 2015,4(1), 231-235.
Po-Chiang Chiang, Yue Shi,Yong Cui,Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-b-cyclodextrin in Aqueous Solution. Pharmaceutics. 2014, 6, 467-480.
Po-Chang Chiang and Harvey Wong. Nanosuspension Delivery of Paclitaxel to Xenograft Mice Can Alter Drug Disposition and Anti-tumor Activity. NanoScale research Letter. 2014. 9,158.
Po-Chang Chiang & Harvey Wong. Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin. 2013. AAPS J (2013), 15(4), 1109-1118.
Yong Cui, Po-Chang Chiang, Edna F. Choo, Jason Boggs, Joachim Rudolph, Jonas Grinad, Steve Wenglowsky, Yingqing Ran, Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-RAF (Rapidly Accelerated Fibrosarcoma) inhibitor. Int. J. Pharm. 2013, 454,241-248.
Po-Chang Chiang, Haiming Zhang, Hank La and Harvey Wong. Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling. Mole. Pharm. 2013, 10 (11),3980–3988.
Po-Chang Chiang, Yong Cui, Joe Lubach, Yingqing Ran, Kang-Jye Chou, Wei Jia, Linda Bao, Jonathan Hau, Amy Sambrone, Hank La, Ann Qin, Yuzhong Deng, and Harvey Wong. In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench Scale Processes, Using Griseofulvin as a Model Compound. AAPS journal. 2 (2013), 608-617.
Daniels J Scott; Lai Yurong; South Sarah; Chiang Po-Chang; Walker Daniel; Feng Bo; Mireles Rouchelle; Whiteley Laurence O; McKenzie Jeremy W; Stevens Jeffrey; Mourey Robert; Anderson David; Davis John WInhibition of Hepatobiliary Transporters by A Novel Kinase Inhibitor Contributes to Hepatotoxicity in Beagle Dog. Drug metabolism letters. 1872-3128. 2013.
Po-Chang Chiang, Yuzhong Deng, Savita Ubhayaka, Hank La, Yong Cui, Kang-Jye Chou, Yingqing Ran, and Harvey Wong. Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications. J. Nanosci. Nanotechnol. 12, 7993-8000 (2012) .
Po-Chang Chiang; Kang-Jye Chou, Yong Cui, Amy Sambrone, Connie Chan, Ryan Hart, and Yingqing Ran. Evaluation of spray-dried drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery. AAPS Pharm. Sci. Tech. (2012). 13(2): 713–722.
Po-Chang Chiang; Thompson, David C.; Ghosh, Sarbani; Heitmeier, Monique R. A formulation-enabled pre-clinical efficacy assessment of a farnesoid X receptor (FXR) agonist, GW4064, in hamsters and cynomolgous monkeys. J. Pharm. Sci. 2011. 100(11).4722-4733.
Po-Chang Chiang; Ran Yingqing; Chou Kang-Jye; Cui Yong; Wong Harvey. Investigation of utilization of nanosuspension formulation to enhance exposure of 1, 3-Dicyclohexylurea in rats: preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery Nanoscale Res. Lett. 2011. 6. 413.
Po-Chang Chiang; South Sarah A; Wene Steve P. The Impact of Dosing Interval in a Novel Tandem Oral Dosing Strategy: Enhancing the Exposure of Low Solubility Drug Candidates in a Pre-Clinical Setting. J. Drug Delivery. Volume 2011, Article ID 528284, 9 pages.
Po-Chang Chiang; Hu, Yiding; Blom, Jason D.; Thompson, David C. et al., Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations. Nanoscale Res Lett. 2010. 5(6). 1010-1019.
Po-Chang Chiang; South, Sarah A.; Foster, Kimberly A.; Daniels, J. Scott; Wene, Steve P.; Albin, Lesley A.; Thompson, David C. Utilization a Novel Tandem Oral Dosing Strategy to Enhance Exposure of Low Solubility Drug Candidates in Pre-Clinical Setting. J. Pharm. Sci. 2010. 99(7). 3132-3140.
Jon G. Selbo and Po-Chang Chiang. ADMET for Medicinal Chemists. Chapter 3 ; Absorption and Physicochemical Properties of the NCE. Wiley (New York) published 2010.
Po-Chang Chiang; Kishore, Nandini N.; Thompson, David C. Combined Use of Pharmacokinetic Modeling and a steady State Delivery Approach Allow Early Assessment of IκB Kinase-2 (IKK-2) Target Safety and Efficacy. J. Pharm. Sci. 2010. 99(3). 1278-1287.
Cynthia D. Sommers, Janice M. Thompson, Julia A. Guzova, Sheri L. Bonar, Randall K.Rader, Sumathy Mathialagan, Neetu Venkatraman, Vicky Walker Holway, Larry E. Kahn, George Hu, Debra S. Garner, Horng-Chih Huang, Po-Chang Chiang, John F.Schindler, Yiding Hu, Debra M. Meyer, Nandini N. Kishore.Novel Tight Binding Inhibitory Factor- κB Kinase Inhibitors (IKK-2) Demonstrate Target Specific Anti-inflammatory Activities in Cellular Assays and Following Oraland Local Delivery in an In Vivo Model of Airway Inflammation. J. Pharm. Exp. Thera.( JPET). 2009. 330(2).377-388.
Adam Schoeel, Bruce Hyde, Po-Chang Chiang, Yiding Hu and David Tung. The Development of a Novel Euthanasia Method for Mice in Support of Rapid Time Course Pulmonary Pharmacokinetic Studies. Journal of the American Association for Laboratory Animal Science. 2009,48(5),506-511.
Gabriel Mbalaviele, Cynthia D. Sommers, Sheri L. Bonar, Sumathy Mathialagan, John F. Schindler, Julia A. Guzova, Alexander F. Shaffer, Michele A. Melton, Lori J. Christine, Catherine S. Tripp, Po-Chang Chiang, David C. Thompson, Yiding Hu, and Nandini Kishore. A Novel, Highly Selective, Tight Binding I&[kappa]B kinase-2 (IKK-2) Inhibitor: a Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the NF-&[kappa]B Pathway in Arthritis Relevant Cells and Animal Models. J. Pharm. Exp. Thera.( JPET). 2009. 329(1), 14-29.
Po-Chang Chiang; Hu, Yiding; Thurston, Archie; Sommers, Cynthia D.; Guzova, Julia A.; Kahn, Larry E.; Lai, Yurong; Blom, Jason D. et al, Pharmacokinetic and Pharmacodynamic Evaluation of the Suitability of Using Fluticasone and an Acute Rat Lung Inflammation Model to Differentiate Lung vs. Systemic Efficacy. J. Pharm. Sci. 2009.98(11). 4354-4364.
Po-Chang Chiang; Hu, Yiding. Simultaneous determination of LogD, LogP, and pKa of drugs by using a 96-well plate RP HPLC and its in vivo correlation. J. of Combinatorial Chemistry & High Throughput Screening. 2009, 12(3),250-257.
Po-Chang Chiang ; South, Sarah A.; Daniels, J. Scott; Anderson, David R.; Wene, Steve P.; Albin, Lesley A.; Mourey, Robert J.; Selbo, Jon G. Aqueous vs. Non-aqueous Salt Delivery Strategies to Enhance Oral Bioavailability of a Mitogen Activated Protein Kinase Activated Protein Kinase (MK-2) Inhibitor in Rats. J. Pharm Sci. 2009. 98(1), 248-256.
Po-Chang Chiang; Alsup, Jason W.; Lai, Yurong; Hu, Yiding; Heyde, Bruce R.; Tung, David. Evaluation of Aerosol Delivery of Nanosuspension for Preclinical Pulmonary Drug Delivery. Nanoscale Res. Lett. 2009. 4(3). 254-261.
Yurong Lai and Po-Chang Chiang ( both 1st author) et al., Comparison of In Vitro Nanoparticles Uptake in Various Cell Lines and In Vivo Pulmonary Cellular uptake in Intratracheally Dosed Rat Model. Nanoscale Res. Lett . 2008, 3 (9) , 321-329.
Sarbani Ghosh; Po-Chang Chiang (both 1st author) ; Wahlstrom Jan L; Fujiwara Hideji; Selbo Jon G; Roberds Steven L Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic & Clinical Pharmacology & Toxicology 2008, 125(5) 453-458.
Po-Chang Chiang, Jay C. Means " Quantification of Benzo[a]pyrene-Guanine Adducts in in vitro Samples by LC Tandem Mass Spectrometry with Stable Isotope Internal Standardization". Journal of Liquid Chromatography & Related Technologies. 2008,31 (20), 3169-3193.
J. Yang; A. Young; Po-Chang Chiang ; Thurston Archie; Pretzer Denise K Fluticasone and Budesonide Nanosuspensions for Pulmonary Delivery: Preparation, Characterization, and Pharmacokinetic Studies. J. Pharm. Sci. 2008,97(11),4869-4878.
Po-Chang Chiang ; Wahlstrom, Jan L.; Selbo, Jon G.; Zhou, Shuxia; Wene, Steve P.; Albin, Lesley A.; Warren, Chad J.; Smith, Mark E.; Roberds, Steven L.; Ghosh, Sarbani; Zhang, L. Lena; Pretzer, Denise K. 1,3 Dicyclohexyl Urea Nanosuspension for Intravenous Steady-State Delivery in Rat. Molecular Simulation / Journal of Experimental Nanoscience 2007. 2(3). 239-250.
Jan L Wahlstrom; Po-Chang Chiang ; Ghosh, Sarbani; Warren, Chad J.; Wene, Steve P.; Albin, Lesley A.; Smith, Mark E.; Roberds, Steven L. Pharmacokinetic Evaluation of a N,N’-Dicyclohexylurea Nanosuspension Formulation to Support Early Efficacy Assessment. Nanoscale Res Lett .2007, 2, 291–296.
Po-Chang Chiang; Foster, Kimberly A.; Whittle, Marie C.; Su, Ching-Chiang; Pretzer, Denise K. Medium through put pKa determinations of drugs and chemicals by using a reverse phase HPLC with organic gradient”. Journal of Liquid Chromatography & Related Technologies. 2006, 29, 2291-230.
Po-Chang Chiang; Su, Ching-Chiang; Block, Katherine; Pretzer, Denise. Medium through put pKa determinations of drugs and chemicals by using a HPLC equipped with DAD as a flow injection apparatus. Journal of Liquid Chromatography & Related Technologies. 2005, 28, 3035-3043.