Lin, CW; Sherman, B; Moore, LA; Laethem, CL; Lu, DW; Pattabiraman PP; Rao, PV; deLong, MA;Kopczynski, C. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. Journal of Ocular Pharmacology and Therapeutics. 2017.
Rao PV, Pattabiraman PP, Kopczynski C. Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. Exp Eye Res. 2016 Sep 1. pii:S0014-4835(16)30240-8.
Pattabiraman PP, Toris CB. The exit strategy: Pharmacological modulation of extracellular matrix production and deposition for better aqueous humor drainage. Eur J Pharmacol. 2016 Apr 23. pii: S0014-2999(16)30274-6.
Pattabiraman PP, Rao PV. Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. Invest. Ophthalmol. Vis.Sci. 2015;56(9):5656-5669.
Pattabiraman PP, Inoue T, Rao PV. Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. Exp Eye Res. 2015 May 5;136:29-33.
Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512.
Pattabiraman PP, Maddala R, Rao PV. Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling. J Cell Physiol. 2014 Jul;229(7):927-42.
PP Pattabiraman, DL Epstein, P Vasantha Rao. Regulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their Influence on Intraocular Pressure. J Ocular Biol 2013 1 (1), 10.
Pattabiraman PP, Pecen PE, Rao PV. MRP4-Mediated Regulation of Intracellular cAMP and cGMP Levels in Trabecular Meshwork Cells and Homeostasis of Intraocular Pressure. Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1636-49.
Iyer P, Maddala R, Pattabiraman PP, Rao PV. Connective Tissue Growth Factor-Mediated Upregulation of Neuromedin-U Expression in Trabecular Meshwork Cells and its Role in Homeostasis of Aqueous Humor Outflow. Invest Ophthalmol Vis Sci. 2012 Jul 3.
Pattabiraman PP, Lih FB, Tomer KB, Rao PV. The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. Am J Physiol Cell Physiol. 2012 Apr; 302(7): C979-91.
Inoue T, Pecen P, Maddala R, Skiba NP, Pattabiraman PP, Epstein DL, Rao PV. Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12): 6461-71.
Inoue T, Pattabiraman PP, Epstein DL, Rao PV. Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. Exp Eye Res. 2010 Feb; 90(2): 360-7.
Pattabiraman PP, Rao PV. Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar; 298(3): C749-63.
Calamusa M, Pattabiraman PP, Pozdeyev N, Iuvone PM, Cellerino A, Domenici L. Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice. Vision Res. 2007 May; 47(11): 1523-36.
Pattabiraman PP, Tropea D, Chiaruttini C, Tongiorgi E, Cattaneo A, Domenici L. Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol Cell Neurosci. 2005 Mar; 28(3): 556-70.